Changes in basophil activation during immunotherapy with house dust mite and mugwort in patients with allergic rhinitis

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Changes in basophil activation during immunotherapy with house dust mite and mugwort in patients with allergic rhinitis

Background The basophil activation test (BAT) is a promising tool for monitoring allergen-specific immunotherapy responses. Objective We aimed to investigate the changes in basophil activation in response to the inhalant allergens of house dust mite (HDM) and mugwort pollen during immunotherapy in patients with allergic rhinitis. Methods We enrolled patients with allergic rhinitis who were ...

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The usefulness of the basophil activation test in monitoring specific immunotherapy with house dust mite allergens

Introduction In clinical practice, reliable tools for monitoring specific immunotherapy (SIT) are of utmost importance. Aim To assess the usefulness of the basophil activation test (BAT) in monitoring SIT in paediatric patients with allergy to house dust mites (HDM). Material and methods Thirty-one children qualified for SIT with HDM, of whom 21 completed the SIT during the observation peri...

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Early Intervention Improves Clinical Responses to House Dust Mite Immunotherapy in Allergic Rhinitis Patients.

BACKGROUND Allergen immunotherapy (AIT) is the unique causal treatment for respiratory allergy. As AIT is expensive and of long duration, the availability of a marker predicting AIT responders is of crucial relevance. OBJECTIVE To investigate clinical parameters correlated with effective AIT in allergic rhinitis (AR) patients. METHODS This is a prospective, nonrandomized open study in which...

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House dust mite sublingual tablet is effective and safe in patients with allergic rhinitis

BACKGROUND House dust mite (HDM) is the major indoor allergen for allergic diseases such as allergic rhinitis (AR) and asthma. Although sublingual immunotherapy is a curative treatment for HDM-induced AR, data from large-scale studies are limited. We evaluated the efficacy and safety of HDM tablets in adolescent and adult patients (aged 12-64 years) with HDM-induced AR with or without intermitt...

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Dose-Dependent Immunological Responses after a 6-Month Course of Sublingual House Dust Mite Immunotherapy in Patients with Allergic Rhinitis.

BACKGROUND House dust mite (HDM) immunotherapy has proven efficacy in treating allergic rhinitis (AR) symptoms. This trial evaluated the dose-response relationship of SLIToneULTRA® HDM mix based on immunological parameters and safety in subjects with moderate-to-severe HDM AR not controlled by symptomatic medication. MATERIALS AND METHODS A randomized, parallel-group, open-label, clinical tri...

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ژورنال

عنوان ژورنال: Asia Pacific Allergy

سال: 2018

ISSN: 2233-8276,2233-8268

DOI: 10.5415/apallergy.2018.8.e6